Antibodiyite za monoclonal zishobora gusimbuza opioide kubabara karande?

Mu gihe cy'icyorezo, abaganga bakoresha antibodiyite zatewe (antibodies zakozwe na laboratoire) kugira ngo bafashe abarwayi kurwanya indwara ya COVID-19. Ubu abashakashatsi ba UC Davis baragerageza gukora antibodiyite za monoclonal zishobora gufasha kurwanya ububabare budashira. Intego ni uguteza imbere ububabare butagabanije buri kwezi bushobora gusimbuza opioide.
Uyu mushinga uyobowe na Vladimir Yarov-Yarovoi na James Trimmer, abarimu mu ishami rya Physiologiya na Biologiya ya Membrane muri kaminuza ya Californiya, Ishuri ry'ubuvuzi rya Davis. Bakoranyirije hamwe itsinda ryinshi ryarimo benshi mubashakashatsi bamwe bagerageje guhindura ubumara bwa tarantula mububabare.
Mu ntangiriro zuyu mwaka, Yarov-Yarovoy na Trimmer bahawe inkunga ingana na miliyoni 1.5 y’amadorali yatanzwe na gahunda y’ubuzima y’ikigo cy’igihugu cyita ku buzima, kikaba ari igerageza rikomeye mu kwihutisha ibisubizo bya siyansi kugira ngo ikibazo cya opioide kibe mu gihugu.
Kubera ububabare budashira, abantu barashobora kwizizirwa na opioide. Ikigo gishinzwe kurwanya indwara Ikigo cy’igihugu gishinzwe ibarurishamibare cy’ubuzima kigereranya ko muri 2021 muri Leta zunze ubumwe z’Amerika hapfa abantu barenga 107,622 banywa ibiyobyabwenge, hafi 15% ugereranyije n’impfu zigera ku 93.655 muri 2020.
Yarov yagize ati: "Ibimaze kugerwaho mu binyabuzima ndetse no kubara - gukoresha mudasobwa mu gusobanukirwa no kwerekana imiterere y'ibinyabuzima - byashizeho urufatiro rwo gushyira mu bikorwa uburyo bushya bwo gukora antibodi nk'abakandida b’ibiyobyabwenge mu kuvura ububabare budakira". Yarovoy, umukinnyi mukuru wigihembo cya Sai.
Trimmer yagize ati: "Antibodiyite za Monoclonal ni agace gakura vuba cyane mu nganda zimiti kandi zitanga inyungu nyinshi kurenza imiti ya molekile ntoya". Imiti mito ya molekile ni ibiyobyabwenge byinjira mu ngirabuzimafatizo byoroshye. Zikoreshwa cyane mubuvuzi.
Mu myaka yashize, laboratoire ya Trimmer yakoze ibihumbi n'ibihumbi antibodiyite zitandukanye za monoclonal intego zitandukanye, ariko ubu ni bwo bwa mbere bwo gukora antibody yagenewe kugabanya ububabare.
Nubwo bigaragara ko ari futuristic, Ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge cyemeje antibodiyite za monoclonal zo kuvura no gukumira migraine. Imiti mishya ikora kuri poroteyine ifitanye isano na migraine yitwa peptide ya calcitonine.
Umushinga UC Davis ufite intego zitandukanye - imiyoboro yihariye ya ion mu ngirabuzimafatizo yitwa voltage-gated sodium umuyoboro. Iyi miyoboro ni nka "pore" kuri selile nervice.
“Ingirabuzimafatizo zifite inshingano zo kohereza ibimenyetso by'ububabare mu mubiri. Imiyoboro ya sodium ion ishobora kuba mu ngirabuzimafatizo ni yo yanduza ububabare, ”nk'uko Yarov-Yarovoy abisobanura. Ati: “Intego yacu ni ugukora antibodi zihuza izo mbuga zanduza ku rwego rwa molekile, kubuza ibikorwa byazo no guhagarika kwanduza ibimenyetso by'ububabare.”
Abashakashatsi bibanze ku miyoboro itatu ya sodiumi ifitanye isano n'ububabare: NaV1.7, NaV1.8, na NaV1.9.
Intego yabo ni ugukora antibodies zihuye niyi miyoboro, nkurufunguzo rufungura ifunga. Ubu buryo bugamije bugamije guhagarika kwanduza ibimenyetso byububabare binyuze kumuyoboro bitabangamiye ibindi bimenyetso byanyuze mu ngirabuzimafatizo.
Ikibazo nuko imiterere yimiyoboro itatu bagerageza guhagarika iragoye cyane.
Kugira ngo iki kibazo gikemuke, bahindukirira gahunda ya Rosetta na AlphaFold. Hamwe na Rosetta, abashakashatsi barimo gukora imiterere ya poroteyine igoye kandi banasesengura imiterere ikwiranye n’imiyoboro ya NaV1.7, NaV1.8, na NaV1.9. Hamwe na AlphaFold, abashakashatsi barashobora kwigenga bagerageza poroteyine zakozwe na Rosetta.
Bamaze kumenya poroteyine nke zitanga ikizere, bakoze antibodies zishobora noneho kugeragezwa kumitsi yumubiri yakozwe muri laboratoire. Ibigeragezo byabantu bizatwara imyaka.
Ariko abashakashatsi bishimiye ubushobozi bwubu buryo bushya. Imiti itari steroidal anti-inflammatory (NSAIDs), nka ibuprofen na acetaminofeni, igomba gufatwa inshuro nyinshi kumunsi kugirango igabanye ububabare. Imiti igabanya ububabare bwa Opioid isanzwe ifatwa buri munsi kandi igatwara ibyago byo kwizizirwa.
Ariko, antibodiyite za monoclonal zirashobora kuzenguruka mumaraso mugihe kirenga ukwezi mbere yuko zimeneka numubiri. Abashakashatsi bari biteze ko abarwayi bayobora antibody ya analgesic monoclonal rimwe mu kwezi.
Yarov-Yarovoy yagize ati: "Ku barwayi bafite ububabare budashira, nibyo rwose ukeneye." “Ntibababara iminsi, ariko ibyumweru n'amezi. Biteganijwe ko kuzenguruka antibodiyide bizashobora kugabanya ububabare bumara ibyumweru byinshi. ”
Abandi bagize itsinda barimo Bruno Correia wa EPFL, Steven Waxman wa Yale, William Schmidt wa EicOsis na Heike Wolf, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, na Robert Stewart wo muri UC Davis.
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